Florida State Road 78

The current western terminus of the westernmost piece of SR 78 is in northwest Cape Coral at an intersection with Stringfellow Rd beginning at “Pine Island Center”. Known as Pine Island Road, it travels east from its terminus through northern Cape Coral toward North Fort Myers, Florida, where it intersects U.S. Route 41. SR 78 becomes Bayshore Road in North Fort Myers at its intersection with U.S. Route 41 Business (which is part of an earlier alignment of US 41 and the Tamiami Trail). Bayshore Road continues east paralleling the north shore of the Caloosahatchee River. It intersects with Interstate 75 shortly before terminating at State Road 31 near the Lee County Civic Center.

SR 78 between La Belle and Moore Haven.

The 14-mile-long central east–west section of SR 78 extends from SR 29 four miles (6 km) northeast of North LaBelle to an intersection with US 27/SR 25 midway between Citrus Center and Moore Haven. In between is the town of Ortona. The central section of SR 78 is entirely within a part of Glades County dedicated to the growth of foliage house plants.

The 34-mile-long easternmost section of State Road 78 (SR 78) is signed east–west, even though the bulk of the road is north–south. This stretch follows the western and northern edge of the Lake Okeechobee wetlands. The southern (“western”) terminus of this segment is an intersection with US 27/SR 25 near Moore Haven. Motorists driving “east” (actually north) on SR 78, travel through Sportsman Village before visiting the Brighton Seminole Indian Reservation and Buckhead Ridge before reaching the northern (“eastern”) terminus, an intersection with US 98 (SR 700)-US 441 (SR 15) near Eagle Bay in the northern tip of Lake Okeechobee, roughly three miles to the south of Okeechobee.