Corydaline synthase
In enzymology, a corydaline synthase (EC 2.1.1.147) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + palmatine + 2 NADPH + H+ S-adenosyl-L-homocysteine + corydaline + 2 NADP+
| corydaline synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.147 | ||||||||
| CAS no. | 155807-67-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 4 substrates of this enzyme are S-adenosyl methionine, palmatine, NADPH, and H+, whereas its 3 products are S-adenosylhomocysteine, corydaline, and NADP+.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase.
References
- Rueffer M, Bauer W, Zenk MH (1994). "The formation of corydaline and related alkaloids in Corydalis cava in vivo and in vitro". Can. J. Chem. 72: 170–175. doi:10.1139/v94-026.
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