Collin Y. Ewald

Collin Yvès Ewald (born 1980 in Basel) is a Swiss scientist investigating the molecular mechanisms of healthy aging.[1][2] He is a molecular biologist and a professor at ETH Zurich, where he leads the Laboratory of Extracellular Matrix Regeneration.[3][4] His research focuses on the remodeling of the extracellular matrix during aging and upon longevity interventions.[5][6]

Collin Yvès Ewald
Collin Y. Ewald in 2016
Born1980 (age 42–43)
Basel
CitizenshipSwiss
EducationBiochemistry
Alma materUniversity of Basel
CUNY Graduate Center
Known forMatreotype
Scientific career
FieldsMolecular biology, Genetics, Neuroscience
InstitutionsETH Zurich
ThesisMultifunctional roles of APL-1 in C. elegans (2011)
Doctoral advisorChristine Li
Websitewww.ewaldlab.com

Career

Collin Ewald was educated at Mathematisch-Naturwissenschaftliches Gymnasium (MNG) Basel, Switzerland. After completing his bachelor in molecular biology at the University of Basel, he joined the labs of Joy Alcedo and Nancy Hynes studying the function of a breast cancer metastasis gene Memo1[7] in the model organism C. elegans at the Friedrich Miescher Institute (FMI) for Biomedical Research, Basel, Switzerland. In the Alcedo lab, he became interested in how neurons regulate aging and went on to do a Ph.D. in Neuroscience at the Graduated Center of the City University of New York, USA.[8] Mentored by his Ph.D. supervisor Chris Li, he discovered a conserved genetic link between Insulin/IGF-1 signaling and Alzheimer's disease amyloid precursor protein (APP) orthologues.[9][10] To deepen his knowledge in aging research, he joined T. Keith Blackwell's lab as a postdoctoral fellow at Harvard Medical School, unraveling the importance of Insulin/IGF-1 signaling in promoting collagen homeostasis during longevity.[11][12][13][14] In 2015, he became a Junior Faculty Member at the Joslin Diabetes Center, Instructor in Medicine at Harvard Medical School, and visiting scholar at the Whitehead Institute (Massachusetts Institute of Technology). After ten years in the US, in 2016, he secured the SNSF professorship to return to Switzerland to join the Institute for Translational Medicine.[15] as an assistant professor at ETH Zürich.[16]

To be at the forefront and to interconnect the two research fields of aging and matrix biology, he founded the Swiss Society for Aging Research,[17] is the vice president of the German Society of Aging Research,[18] and he re-established the Swiss Society for Matrix Biology.[19] He is an independent scientific advisor of the longevity-start-up-company-builder Maximon AG,[20][21] and a co-founder of Avea Life AG.[22]

Research

His research centers around the remodeling of the extracellular matrix, ensuring tissue and cellular homeostasis during healthy aging.[23][24] In collaboration with Alexandra Naba, he defined the proteins outside of cells forming the extracellular matrix, the so-called matrisome of C. elegans.[25][26] Over ten thousand phenotypes stem from mutations in matrisome genes in humans and across species.[27] He coined the term matreotype[28][29] that is the extracellular matrix composition caused or associated by a cellular or physiological status, genotype, or phenotype. Using gene expression data from humans at different ages and tissues, his team defined the youthful matreotype and used it to predict drugs that slow aging.[30]  His research group also showed that even close to the end of an individual's life, it is possible to double the lifespan of C. elegans.[31]

Distinctions

He is named under the top 15 Longevity Influencer in Switzerland[32] and world influencer ETH domain,[33] Who is Who in Medical Research,[34] is in the top 0.5% of the worldwide longevity experts,[35] and has received multiple awards, including the Ellison Medical Foundation and American Federation for Aging Research fellowship in 2013,[36] the DeLill Nasser Award in 2015,[37] and the SNSF Professorship in 2016.[38]

Selected works

References
  1. "Dem Alter auf der Spur - Jung bleiben bis ins hohe Alter: Das sagt die Forschung". Schweizer Radio und Fernsehen (SRF) (in German). 2018-08-12. Retrieved 2021-11-25.
  2. "Gesundes Altern – Fit wie Joe Biden – wie bleibt man im Alter lange gesund?". Tages-Anzeiger (in German). Retrieved 2021-11-25.
  3. "23 professors appointed at ETH Zurich and EPFL | ETH-Board". www.ethrat.ch. Retrieved 2021-12-02.
  4. Sciences, Address ETH Zürich Dep of Health; Switzerl, Technology Prof Dr Collin Ewald Regenerat Extrazellulärer Matrix SLA C. 8 Schorenstrasse 16 8603 Schwerzenbach. "Ewald, Collin, Prof. Dr. | ETH Zurich". hest.ethz.ch. Retrieved 2021-11-25.
  5. "Ewaldlab". Ewaldlab. Retrieved 2021-11-25.
  6. "Einführungs- und Abschiedsvorlesungen | ETH Zürich Videoportal". video.ethz.ch. Retrieved 2021-11-25.
  7. Ewald, Collin Yvès; Hourihan, John M; Bland, Monet S; Obieglo, Carolin; Katic, Iskra; Moronetti Mazzeo, Lorenza E; Alcedo, Joy; Blackwell, T Keith; Hynes, Nancy E (2017-01-13). "NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans". eLife. 6: e19493. doi:10.7554/eLife.19493. ISSN 2050-084X. PMC 5235354. PMID 28085666.
  8. "Collin Ewald". www.gc.cuny.edu. Retrieved 2021-11-25. Archived version
  9. Ewald, Collin Y; Raps, Daniel A; Li, Chris (2012-06-01). "APL-1, the Alzheimer's Amyloid Precursor Protein in Caenorhabditis elegans, Modulates Multiple Metabolic Pathways Throughout Development". Genetics. 191 (2): 493–507. doi:10.1534/genetics.112.138768. ISSN 1943-2631. PMC 3374313. PMID 22466039.
  10. "Alzheimer's gene 'diabetes link'". BBC News. 2012-06-15. Retrieved 2021-11-25.
  11. "Discovery may hold clues to treatments that slow aging, prevent age-related chronic disease". ScienceDaily. Retrieved 2021-11-25.
  12. Center, Joslin Diabetes. "Discovery may hold clues to treatments that slow aging". medicalxpress.com. Retrieved 2021-11-25.
  13. "Long Live Collagen". The Scientist Magazine®. Retrieved 2021-11-25.
  14. "Grantee in the News: Collin Ewald's Research Explores Collagen and Longevity". American Federation for Aging Research. Retrieved 2021-11-25.
  15. "People". itm.ethz.ch. Retrieved 2021-11-25.
  16. "«Covidisierung» der Forschung verzögert andere Projekte - Echo der Zeit - SRF". Schweizer Radio und Fernsehen (SRF) (in German). Retrieved 2021-11-26.
  17. "Swiss Society for Aging Research". Swiss Society for Aging Research. Retrieved 2021-11-26.
  18. "DGfA e.V. I Deutsche Gesellschaft für Alternsforschung". alternsforschung.org. Retrieved 2021-11-26.
  19. "SSMB". SSMB. Retrieved 2021-11-26.
  20. "Longevity". Maximon. Retrieved 2021-11-26.
  21. "#008: Marc Bernegger, Tobias Reichmuth, Collin Ewald (Maximon) - April 8th, 2021". Longevity Biotech Show. 2021-04-08. Retrieved 2021-11-26.
  22. "AVEA". AVEA (in German). Retrieved 2021-11-26.
  23. Collin Ewald presents at ARDD 2021, retrieved 2021-11-26
  24. Nano - Play SRF (in German), retrieved 2021-11-26
  25. Teuscher, Alina C.; Jongsma, Elisabeth; Davis, Martin N.; Statzer, Cyril; Gebauer, Jan M.; Naba, Alexandra; Ewald, Collin Y. (February 2019). "The in-silico characterization of the Caenorhabditis elegans matrisome and proposal of a novel collagen classification". Matrix Biology Plus. 1: 100001. doi:10.1016/j.mbplus.2018.11.001. PMC 7852208. PMID 33543001.
  26. "Matrisome.org". matrisome.org. Retrieved 2021-11-26.
  27. Statzer, Cyril; Ewald, Collin Y. (November 2020). "The extracellular matrix phenome across species". Matrix Biology Plus. 8: 100039. doi:10.1016/j.mbplus.2020.100039. PMC 7852310. PMID 33543035.
  28. Ewald, Collin Ivès (2020). "The Matrisome during Aging and Longevity: A Systems-Level Approach toward Defining Matreotypes Promoting Healthy Aging". Gerontology. 66 (3): 266–274. doi:10.1159/000504295. ISSN 0304-324X. PMC 7214094. PMID 31838471.
  29. Superhighway of Our Cells: Extracellular Matrix With Prof Collin Ewald, retrieved 2021-11-26
  30. Statzer, Cyril; Jongsma, Elisabeth; Liu, Sean X.; Dakhovnik, Alexander; Wandrey, Franziska; Mozharovskyi, Pavlo; Zülli, Fred; Ewald, Collin Y. (September 2021). "Youthful and age‐related matreotypes predict drugs promoting longevity". Aging Cell. 20 (9): e13441. doi:10.1111/acel.13441. ISSN 1474-9718. PMC 8441316. PMID 34346557.
  31. Venz, Richard; Pekec, Tina; Katic, Iskra; Ciosk, Rafal; Ewald, Collin Ivès (2021-09-10). "End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies". eLife. 10: e71335. doi:10.7554/eLife.71335. ISSN 2050-084X. PMC 8492056. PMID 34505574.
  32. "Why Switzerland". Longevity Swiss. Retrieved 2021-11-26.
  33. "ETH / EPFL | Influencer World Ranking". ranking.influencer.world. Retrieved 2021-11-25.
  34. "Who is Who in Medical Research". www.hochschulmedizin.uzh.ch. Retrieved 2021-11-26.
  35. "Longevity: Ewald, Collin Y - Expertscape.com". expertscape.com. Retrieved 2021-11-25.
  36. "2019 Grant Recipients". American Federation for Aging Research. Retrieved 2021-11-26.
  37. "DeLill Nasser Award for Professional Development in Genetics". Genetics Society of America. Retrieved 2021-11-26.
  38. "SNSF | P3 Research Database | Project 163898". p3.snf.ch. Retrieved 2021-11-26.
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