Cephalosporin-C transaminase
In enzymology, a cephalosporin-C transaminase (EC 2.6.1.74) is an enzyme that catalyzes the chemical reaction
- (7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate cephalosporin C + 2-oxoglutarate
| cephalosporin-C transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.6.1.74 | ||||||||
| CAS no. | 122096-91-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are (7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate and D-glutamate, whereas its two products are cephalosporin C and 2-oxoglutarate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is cephalosporin-C:2-oxoglutarate aminotransferase. Other names in common use include cephalosporin C aminotransferase, and L-alanine:cephalosporin-C aminotransferase. This enzyme participates in penicillin and cephalosporin biosynthesis.
References
- Aretz W, Sauber K (1988). "Novel D-amino acid transaminase". Ann. N. Y. Acad. Sci. 542: 366–70. PMID 3228235.
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