Cationic amino acid transporter 2

SLC7A2
Identifiers
Aliases	SLC7A2, ATRC2, CAT2, HCAT2, solute carrier family 7 member 2
External IDs	OMIM: 601872 MGI: 99828 HomoloGene: 20659 GeneCards: SLC7A2
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	17,570,573 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	41,375,345 bp[2]
RNA expression pattern
	Top expressed in
	biceps brachii; ; islet of Langerhans; ; right lobe of liver; ; trigeminal ganglion; ; gastrocnemius muscle; ; bronchial epithelial cell; ; retinal pigment epithelium; ; pericardium; ; body of pancreas; ; caput epididymis;
	Top expressed in
	dermal bone; ; left lobe of liver; ; human mandible; ; maxilla; ; secondary oocyte; ; islet of Langerhans; ; ciliary body; ; iris; ; aortic valve; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	high-affinity lysine transmembrane transporter activity; low-affinity L-arginine transmembrane transporter activity; L-arginine transmembrane transporter activity; basic amino acid transmembrane transporter activity; high-affinity L-arginine transmembrane transporter activity; high-affinity L-ornithine transmembrane transporter activity; L-ornithine transmembrane transporter activity; L-lysine transmembrane transporter activity; amino acid transmembrane transporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane; cell junction;
Biological process	nitric oxide biosynthetic process; cellular amino acid metabolic process; nitric oxide production involved in inflammatory response; regulation of inflammatory response; L-lysine import across plasma membrane; L-arginine import across plasma membrane; L-ornithine import across plasma membrane; macrophage activation; L-ornithine transmembrane transport; amino acid transport; regulation of macrophage activation; transmembrane transport; L-lysine transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6542
	11988
	ENSG00000003989
	ENSMUSG00000031596
	P52569
	P18581
	NM_001008539; NM_001164771; NM_003046; NM_001370337; NM_001370338
	NM_001044740; NM_007514
	NP_001008539; NP_001158243; NP_003037; NP_001357266; NP_001357267
	NP_001038205; NP_031540
	Wikidata
View/Edit Human	View/Edit Mouse

Cationic amino acid transporter 2 is a protein that in humans is encoded by the SLC7A2 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000003989 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000031596 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hoshide R, Ikeda Y, Karashima S, Matsuura T, Komaki S, Kishino T, Niikawa N, Endo F, Matsuda I (Mar 1997). "Molecular cloning, tissue distribution, and chromosomal localization of human cationic amino acid transporter 2 (HCAT2)". Genomics. 38 (2): 174–8. doi:10.1006/geno.1996.0613. PMID 8954799.
"Entrez Gene: SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2".

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
González M, Flores C, Pearson JD, et al. (2005). "Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells". Pflügers Arch. 448 (4): 383–94. doi:10.1007/s00424-004-1261-x. PMID 15064952. S2CID 25238852.
Schnorr O, Suschek CV, Kolb-Bachofen V (2003). "The importance of cationic amino acid transporter expression in human skin". J. Invest. Dermatol. 120 (6): 1016–22. doi:10.1046/j.1523-1747.2003.12139.x. PMID 12787129.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hammermann R, Brunn G, Racké K (2002). "Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4". Amino Acids. 21 (2): 211–9. doi:10.1007/s007260170029. PMID 11665818. S2CID 30892800.
Closs EI, Gräf P, Habermeier A, et al. (1997). "Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties". Biochemistry. 36 (21): 6462–8. doi:10.1021/bi962829p. PMID 9174363.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000003989 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031596 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8954799-5] Hoshide R, Ikeda Y, Karashima S, Matsuura T, Komaki S, Kishino T, Niikawa N, Endo F, Matsuda I (Mar 1997). "Molecular cloning, tissue distribution, and chromosomal localization of human cationic amino acid transporter 2 (HCAT2)". Genomics. 38 (2): 174–8. doi:10.1006/geno.1996.0613. PMID 8954799.

[entrez-6] "Entrez Gene: SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2".

Cationic amino acid transporter 2

See also

References

Further reading