Carbazole alkaloids

The carbazole alkaloids are natural products of the indole alkaloid type, derived from carbazole.[1]

Carbazole, parent compound of the carbazole alkaloids
Foliage leaves and fruits of Ochrosia elliptica
Fruits of Glycosmis pentaphylla

Occurrence

Carbazole alkaloids with unsubstituted benzene rings occur rarely. Olivacin has been found in the bark of Aspidosperma olivaceum and ellipticin in Ochrosia elliptica.[2] Some carbazole alkaloids, especially glybomin B, have been isolated from Glycosmis pentaphylla.[3]

Representatives

Representatives include, among others, glycozoline, olivacine and ellipticin[2] and further glybomine B.[3]

  • Glycozoline
    Glycozoline
  • Olivacine
    Olivacine
  • Ellipticin
    Ellipticin
  • Glybomine B
    Glybomine B

Properties

Carbazole alkaloids have cytotoxic and antifungal properties. Furthermore, they have detrimental effects against HIV viruses and tumor cells.[3] Olivacin has fluorescent properties.[2]

References
  1. Entry on carbazole alkaloids. In: Römpp Online. Georg Thieme Verlag, accessed May 31, 2020.
  2. Eberhard Breitmaier (1997), Alkaloide, Wiesbaden: Springer Fachmedien, p. 49, ISBN 978-3-519-03542-8
  3. G. Yang, Y. Wu, Y. Chen (2012), "Alkaloids from the Stems of Glycosmis pentaphylla", Helvetica Chimica Acta, vol. 95, no. 8, pp. 1449–1454, doi:10.1002/hlca.201200027{{citation}}: CS1 maint: multiple names: authors list (link)
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