Calmodulin-lysine N-methyltransferase
In enzymology, a calmodulin-lysine N-methyltransferase (EC 2.1.1.60) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + calmodulin L-lysine S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
| calmodulin-lysine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.60 | ||||||||
| CAS no. | 75603-20-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl methionine and calmodulin L-lysine, whereas its two products are S-adenosylhomocysteine and calmodulin N6-methyl-L-lysine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase. Other names in common use include S-adenosylmethionine:calmodulin (lysine) N-methyltransferase, and S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase. This enzyme participates in lysine degradation.
References
- Sitaramayya A, Wright LS, Siegel FL (1980). "Enzymatic methylation of calmodulin in rat brain cytosol". J. Biol. Chem. 255 (18): 8894–900. PMID 6773954.
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