CWC15

CWC15
Identifiers
Aliases	CWC15, AD002, C11orf5, Cwf15, HSPC148, ORF5, CWC15 spliceosome-associated protein, CWC15 spliceosome associated protein homolog
External IDs	MGI: 1913320 HomoloGene: 9499 GeneCards: CWC15
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	94,973,586 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	14,421,873 bp[2]
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; vastus lateralis muscle; ; biceps brachii; ; body of tongue; ; Achilles tendon; ; superior surface of tongue; ; deltoid muscle; ; lactiferous duct; ; external globus pallidus; ; pons;
	Top expressed in
	morula; ; yolk sac; ; lip; ; ganglionic eminence; ; supraoptic nucleus; ; mirror; ; cumulus cell; ; spermatocyte; ; thymus; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	catalytic step 2 spliceosome; spliceosomal complex; nucleus; nucleoplasm; mitochondrion; nuclear speck; U2-type catalytic step 2 spliceosome;
Biological process	mRNA processing; RNA splicing; mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	51503
	66070
	ENSG00000150316
	ENSMUSG00000004096
	Q9P013
	Q9JHS9
	NM_016403; NM_001363371; NM_001363372
	NM_023153
	NP_057487; NP_001350300; NP_001350301
	NP_075642
	Wikidata
View/Edit Human	View/Edit Mouse

Protein CWC15 homolog is a protein that in humans is encoded by the CWC15 gene.[5][6][7]

Interactions

CWC15 has been shown to interact with CDC5L.[8]

GRCh38: Ensembl release 89: ENSG00000150316 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000004096 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
O'Brien KP, Tapia-Paez I, Stahle-Backdahl M, Kedra D, Dumanski JP (Jul 2000). "Characterization of five novel human genes in the 11q13-q22 region". Biochem Biophys Res Commun. 273 (1): 90–4. doi:10.1006/bbrc.2000.2910. PMID 10873569.
Ohi MD, Link AJ, Ren L, Jennings JL, McDonald WH, Gould KL (Mar 2002). "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs". Mol Cell Biol. 22 (7): 2011–24. doi:10.1128/MCB.22.7.2011-2024.2002. PMC 133674. PMID 11884590.
"Entrez Gene: HSPC148 hypothetical protein HSPC148".
Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

Human CWC15 genome location and CWC15 gene details page in the UCSC Genome Browser.

Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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