C9orf156

Chromosome 9 open reading frame 156 is a protein that in humans is encoded by the C9orf156 gene.[1] The gene is also known as NAP1 and HSPC219; the orthologue in mice is 5830415F09Rik.[1]

Model organisms

*5830415F09Rik* knockout mouse phenotype
Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Salmonella infection	Normal[2]
Citrobacter infection	Normal[3]
All tests and analysis from[4][5]

Model organisms have been used in the study of C9orf156 function. A conditional knockout mouse line, called 5830415F09Rik^{tm1a(EUCOMM)Wtsi}[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty four tests were carried out on mutant mice, but no significant abnormalities were observed.[4]

References

"Chromosome 9 open reading frame 156". Retrieved 2011-12-11.
"Salmonella infection data for 5830415F09Rik". Wellcome Trust Sanger Institute.
"Citrobacter infection data for 5830415F09Rik". Wellcome Trust Sanger Institute.
Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
Mouse Resources Portal, Wellcome Trust Sanger Institute.
"International Knockout Mouse Consortium".
"Mouse Genome Informatics".
Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Letra, A.; Menezes, R.; Govil, M.; Fonseca, R. F.; McHenry, T.; Granjeiro, J. M.; Castilla, E. E.; Orioli, I. D. M.; Marazita, M. L.; Vieira, A. R. (2010). "Follow-Up Association Studies of Chromosome Region 9q and Nonsyndromic Cleft Lip/Palate". American Journal of Medical Genetics Part A. 152A (7): 1701–1710. doi:10.1002/ajmg.a.33482. PMC 2898904. PMID 20583170.
Moreno, L. M.; Mansilla, M. A.; Bullard, S. A.; Cooper, M. E.; Busch, T. D.; Machida, J.; Johnson, M. K.; Brauer, D.; Krahn, K.; Daack-Hirsch, S.; l'Heureux, J.; Valencia-Ramirez, C.; Rivera, D.; López, A. M.; Moreno, M. A.; Hing, A.; Lammer, E. J.; Jones, M.; Christensen, K.; Lie, R. T.; Jugessur, A.; Wilcox, A. J.; Chines, P.; Pugh, E.; Doheny, K.; Arcos-Burgos, M.; Marazita, M. L.; Murray, J. C.; Lidral, A. C. (2009). "FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate". Human Molecular Genetics. 18 (24): 4879–4896. doi:10.1093/hmg/ddp444. PMC 2778374. PMID 19779022.

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[entrez-1] "Chromosome 9 open reading frame 156". Retrieved 2011-12-11.

[''Salmonella''_infection-2] "Salmonella infection data for 5830415F09Rik". Wellcome Trust Sanger Institute.

[''Citrobacter''_infection-3] "Citrobacter infection data for 5830415F09Rik". Wellcome Trust Sanger Institute.

[mgp_reference-4] Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.

[5] Mouse Resources Portal, Wellcome Trust Sanger Institute.

[allele_ref-6] "International Knockout Mouse Consortium".

[mgi_allele_ref-7] "Mouse Genome Informatics".

[pmid21677750-8] Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.

[mouse_library-9] Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.

[mouse_for_all_reasons-10] Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.

[pmid21722353-11] van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

C9orf156

Model organisms

References

Further reading