Elizabeth Tulloch

Tulloch at San Diego Comic-Con International in 2011

Tulloch's first acting credit was as R2-D2's "girlfriend" in R2-D2: Beneath the Dome, a mockumentary produced by George Lucas telling the life story of the fictional robot R2-D2 from the Star Wars film series. She starred as "Sally" in the premiere of Sam Forman's play, Quarterlife, which opened at the Pico Playhouse in March 2006. The Los Angeles Times wrote, "Superbly performed... the scene at the end of the play, between Sally (Bitsie Tulloch) and Jack (Clark Freeman), was heartbreaking and beautiful... The lead actress, Bitsie Tulloch, [was] absolutely brilliant."

She was in Lakeview Terrace directed by Neil LaBute, opposite Samuel L. Jackson, Kerry Washington, and Patrick Wilson, and worked with Barbara Hershey on a film called Uncross the Stars. In the fall of 2009 she filmed the romantic comedy Losing Control. Tulloch voiced one of the characters, a wolf called Sweets, in Alpha and Omega, a 3-D computer animated film, which was released in September 2010.

Tulloch played the small role of Norma, an actress in the 1920s starring in a silent movie with a veteran actor, in the award-winning movie The Artist with Jean Dujardin, John Goodman and James Cromwell, which was released by The Weinstein Company in November 2011, and won the 2012 Academy Award for Best Picture. The cast of the movie was nominated for a Critics' Choice Award for Best Ensemble Cast.

In 2012 she starred as one of the titular roles in independent film Caroline and Jackie opposite Marguerite Moreau, which she also co-produced. The film premiered at the Tribeca Film Festival in April 2012, and was released theatrically in May 2013.

Tulloch played Marilyn Sitzman, a witness to the Kennedy assassination, in the 2013 film Parkland, opposite Paul Giamatti, Billy Bob Thornton, Marcia Gay Harden, Jacki Weaver, Jackie Earle Haley, and Zac Efron. The film was produced by Tom Hanks and Gary Goetzman of Playtone, and was released in 2013, to coincide with the 50th anniversary of John F. Kennedy's assassination.

Tulloch has appeared on the television shows House, Cold Case, The West Wing, Moonlight, and Outlaw. In 2007, she filmed a role as a Dharma initiative scientist for the ABC series Lost, but her role was re-cast due to scheduling conflicts with quarterlife.

Tulloch played the lead role in Ed Zwick and Marshall Herskovitz's drama quarterlife, which premiered on NBC in early 2008. While the series was quickly pulled and moved to Bravo, Tulloch was hailed for her performance. The Los Angeles Times wrote: "She's the best realized of the bunch... Tulloch, who plays her, seems destined to be better known."[9] She was often lauded as the "next" Claire Danes: "Will this be the first online show to create a real star? It looks likely: The gorgeous 26-year-old Tulloch clearly possesses Danes-like smarts and magnetism."[10]

In 2009, Tulloch shot one of the three leads in HBO's buzzed-about comedy pilot Washingtonienne based on the book by Jessica Cutler. The pilot was produced by HBO and Sarah Jessica Parker. In early 2010, she filmed Most Likely to Succeed, a half-hour comedy pilot for Imagine Entertainment through the FOX network, and had a recurring role on NBC's Outlaw.

Tulloch was a series regular on the NBC series Grimm (2011–2017). She played the role of Juliette Silverton / Eve in the fantasy police procedural drama set in a world where characters inspired by Grimms' Fairy Tales exist.[11][12] Tulloch's heritage and fluency with the Spanish language were written into the role.

Tulloch played Lois Lane in The CW Arrowverse crossover events "Elseworlds" in 2018 and "Crisis on Infinite Earths" in 2019. The executive producers described the character as "dogged, determined and brave".[13][14][15] In 2021, Tulloch and Tyler Hoechlin reprised their roles as Lois and Superman in the spinoff television series Superman & Lois.[16][17][18]