Bromhexine

Bromhexine is a mucolytic drug used in the treatment of respiratory disorders associated with viscid or excessive mucus.[1] It was developed in the research laboratory of Boehringer Ingelheim in the late 1950s as an active ingredient for pharmaceutical use, patented in 1961, introduced in 1963 under the trademark of Bisolvon® and came into medical use in 1966.[2]

Bromhexine
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability75–80%
MetabolismExtensive hepatic
MetabolitesAmbroxol, others
Elimination half-life12 hr
ExcretionUrine
Identifiers
  • 2,4-Dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.020.622
Chemical and physical data
FormulaC14H20Br2N2
Molar mass376.136 g·mol−1
3D model (JSmol)
  • Brc1cc(c(N)c(Br)c1)CN(C)C2CCCCC2
  • InChI=1S/C14H20Br2N2/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17/h7-8,12H,2-6,9,17H2,1H3 checkY
  • Key:OJGDCBLYJGHCIH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Function

Bromhexine is intended to support the body's mechanisms for clearing mucus from the respiratory tract. It is secretolytic, increasing the production of serous mucus in the respiratory tract, which makes the phlegm thinner and less viscous. This contributes to a secretomotoric effect, allowing the cilia to more easily transport the phlegm out of the lungs. For this reason it is often added to cough syrups.

It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as "secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport".

Bromhexine is contained in various formulations, high and low strength syrups 8 mg/5 ml, 4 mg/5 ml, tablets and soluble tablets (both with 8 mg bromhexine) and solution for oral use 10 mg/5 ml, adapted to the need of the patients. The posology varies with the age and weight, but there are products for all age groups from infant on. Bromhexine is well established and tolerated.

Brand names
  • Barkacin
  • Benadryl Chesty/Forte
  • Bisolvon
  • Brofentol
  • Brofentol Plus
  • Bromex
  • Bromhexin
  • Broncholyte Elixir
  • Cofdex
  • Duro-Tuss Chesty/Forte
  • Dysolvon
  • Flegamina
  • Movex
  • Mucolyte
  • Paxirasol
  • Robitussin Chesty/Forte
  • Solvex
  • Vasican
  • Ventilate Forte (combination of bromhexine and salbutamol)

References
  1. Morton I, Hall J (1999). Concise Dictionary of Pharmacological Agents. Springer. p. 55. ISBN 0-7514-0499-3. Retrieved 2009-06-03.
  2. Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 544. ISBN 9783527607495.
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