BPC-157

BPC-157 (also known as PL 14736) is a pentadecapeptide. It has the amino acid sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val.[1] This peptide has a molecular formula of C62H98N16O22. The PUBCHEM ID is CID 9941957.[2]

The peptide is banned by the World Anti-Doping Agency in 2022 under the S0 category of non-exempt substances.[3]

Research

There are some tentative pre-clinical studies on animals and in vitro suggesting possible benefit in wound healing and bowel disorders although all of these studies come from a single research group.[4][5]

Unapproved marketing

BPC 157 is marketed in functional medicine, although, FDA approval is not issued yet for it to be used in standard medicine.[6]

References
  1. Jelovac, Nikola; Sikiric, Predrag; Rucman, Rudolf; Petek, Marijan; Marovic, Anton; Perovic, Darko; Seiwerth, Sven; Mise, Stjepan; Turkovic, Branko; Dodig, Goran; Miklic, Pavle; Buljat, Gojko; Prkacin, Ingrid (1999). "Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats". European Journal of Pharmacology. 379 (1): 19–31. doi:10.1016/S0014-2999(99)00486-0. PMID 10499368.
  2. "PUBCHEM". pubchem.ncbi.nlm.nih.gov. Retrieved 1 March 2021.
  3. "2022 Prohibited List: SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION)" (PDF). World Anti-Doping Agency. WADA. Retrieved 21 February 2022.
  4. Sikiric, P.; Seiwerth, S.; Brcic, L.; Blagaic, A. B.; Zoricic, I.; Sever, M.; Klicek, R.; Radic, B.; Keller, N.; Sipos, K.; Jakir, A.; Udovicic, M.; Tonkic, A.; Kokic, N.; Turkovic, B.; Mise, S.; Anic, T. (2006). "Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response". Inflammopharmacology. 14 (5–6): 214–21. doi:10.1007/s10787-006-1531-7. PMID 17186181. S2CID 24132425.
  5. Cerovecki, Tomislav; Bojanic, Ivan; Brcic, Luka; Radic, Bozo; Vukoja, Ivan; Seiwerth, Sven; Sikiric, Predrag (September 2010). "Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat". Journal of Orthopaedic Research. 28 (9): 1155–1161. doi:10.1002/jor.21107. ISSN 1554-527X. PMID 20225319. S2CID 22085833.
  6. Sikiric, P; Seiwerth, S; Rucman, R; Kolenc, D; Vuletic, LB; Drmic, D; Grgic, T; Strbe, S; Zukanovic, G; Crvenkovic, D; Madzarac, G; Rukavina, I; Sucic, M; Baric, M; Starcevic, N; Krstonijevic, Z; Bencic, ML; Filipcic, I; Rokotov, DS; Vlainic, J (2016). "Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications". Current Neuropharmacology. 14 (8): 857–865. doi:10.2174/1570159x13666160502153022. PMC 5333585. PMID 27138887.
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