Arabinofuranan 3-O-arabinosyltransferase

Arabinofuranan 3-O-arabinosyltransferase (EC 2.4.2.47, AftC) is an enzyme with systematic name alpha-(1->5)-arabinofuranan:trans,octacis-decaprenylphospho-beta-D-arabinofuranose 3-O-alpha-D-arabinofuranosyltransferase.[1][2] This enzyme catalyses the following chemical reaction:

Adds an alpha-D-arabinofuranosyl group from trans,octacis-decaprenylphospho-beta-D-arabinofuranose at the 3-O-position of an alpha-(1->5)-arabinofuranan chain attached to a beta-(1->5)-galactofuranan chain
Arabinofuranan 3-O-arabinosyltransferase
Identifiers
EC no.2.4.2.47
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme is isolated from Mycobacterium smegmatis.

References
  1. Birch HL, Alderwick LJ, Bhatt A, Rittmann D, Krumbach K, Singh A, Bai Y, Lowary TL, Eggeling L, Besra GS (September 2008). "Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferase". Molecular Microbiology. 69 (5): 1191–206. doi:10.1111/j.1365-2958.2008.06354.x. PMC 2610374. PMID 18627460.
  2. Zhang J, Angala SK, Pramanik PK, Li K, Crick DC, Liav A, Jozwiak A, Swiezewska E, Jackson M, Chatterjee D (August 2011). "Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donors". ACS Chemical Biology. 6 (8): 819–28. doi:10.1021/cb200091m. PMC 3158817. PMID 21595486.
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