Anna Marie Pyle

Anna Marie Pyle is an American academic who is a Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Chemistry at Yale University. and an Investigator for Howard Hughes Medical Institute.[1] Pyle is the president of the RNA Society,[2] the vice-chair of the Science and Technology Steering Committee at Brookhaven National Laboratory, and previously she served as chair of the Macromolecular Structure and Function A Study Section[3] at the National Institutes of Health.

Anna Marie Pyle
Alma materPrinceton University, Columbia University
Scientific career
InstitutionsYale University, University of Colorado

Early life and education

Pyle grew up in Albuquerque, New Mexico, and it was there that she first became interested in science.[4] But it wasn't until after earning her bachelor's degree from Princeton University that she committed to a career in chemistry.[4] In 1990, she graduated from Columbia University with a Ph.D. in chemistry. Pyle went on to postdoc at the University of Colorado until in 1992 she established a research group at Columbia University Medical Center in the Department of Biochemistry and Molecular Biophysics. In 2002, she moved to Yale University.[1]

Research

Pyle joined Yale University in 2002. She researches the architectural features of large RNA molecules and RNA remodeling enzymes using experimental biochemistry and crystallography. such as self-splicing introns and other noncoding RNAs. She has focused her research to understand how large RNAs assemble into specific, stable tertiary structures, and also how ATP-dependent enzymes in the cell recognize and remodel RNA. Specifically, she was successful in crystallizing and solving the structure of a group IIC intron from the bacterium Oceanobacillus iheyensis[5] and moves through the stages of splicing.[6] Pyle's research may be helpful in drug development as RNA's tertiary structure could provide insight into druggable biomolecules.[7][8]

Selected awards and honors

References
  1. "Anna Marie Pyle, Ph.D. | Molecular, Cellular and Developmental Biology". mcdb.yale.edu. Retrieved 2019-03-01.
  2. "RNA Society". Retrieved 2019-03-01.
  3. "MSFA | NIH Center for Scientific Review". public.csr.nih.gov. Retrieved 2019-03-01.
  4. "2016 Annual Meeting Plenary Lecturer: Pyle". www.asbmb.org. Retrieved 2019-03-01.
  5. Toor, Navtej; Keating, Kevin S.; Fedorova, Olga; Rajashankar, Kanagalaghatta; Wang, Jimin; Pyle, Anna Marie (January 2010). "Tertiary architecture of the Oceanobacillus iheyensis group II intron". RNA. 16 (1): 57–69. doi:10.1261/rna.1844010. ISSN 1355-8382. PMC 2802037. PMID 19952115.
  6. Pyle, A. M.; Marcia, M. (2012). "Visualizing Group II Intron Catalysis through the Stages of Splicing". Cell. 151 (3): 497–507. doi:10.2210/pdb4e8k/pdb. PMC 3628766. PMID 23101623. Archived from the original on 2019-03-27. Retrieved 2019-03-01.
  7. "Targeting RNA's tertiary structure". Chemical & Engineering News. Retrieved 2019-03-01.
  8. Pyle, Anna Marie; Zandt, Michael C. Van; Lin Yuan; Adams, Rebecca L.; Jagdmann, G. Erik; Fedorova, Olga (December 2018). "Small molecules that target group II introns are potent antifungal agents". Nature Chemical Biology. 14 (12): 1073–1078. doi:10.1038/s41589-018-0142-0. ISSN 1552-4469. PMC 6239893. PMID 30323219.
  9. "2023 NAS Election". National Academy of Sciences. 2023-05-02. Retrieved 2023-05-02.
  10. "Anna Marie Pyle appointed Sterling Professor". YaleNews. 2018-07-19. Retrieved 2019-03-01.
  11. "Historic Fellows". American Association for the Advancement of Science. Retrieved 2019-03-01.
  12. "Anna Marie Pyle". American Academy of Arts & Sciences. Retrieved 2019-03-01.
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