Alpha-amyrin synthase
α-Amyrin synthase (EC 5.4.99.40, 2,3-oxidosqualene alpha-amyrin cyclase, mixed amyrin synthase) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, alpha-amyrin-forming).[1] This enzyme catalyses the following chemical reaction
- (3S)-2,3-epoxy-2,3-dihydrosqualene alpha-amyrin
| α-Amyrin synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.4.99.40 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This multifunctional enzyme produces both alpha- and beta-amyrin.
References
- Morita M, Shibuya M, Kushiro T, Masuda K, Ebizuka Y (June 2000). "Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase". European Journal of Biochemistry. 267 (12): 3453–60. doi:10.1046/j.1432-1327.2000.01357.x. PMID 10848960.
External links
- Alpha-amyrin+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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