Alcohol dehydrogenase, iron containing 1

ADHFE1
Identifiers
Aliases	ADHFE1, ADH8, HOT, HMFT2263, alcohol dehydrogenase, iron containing 1, alcohol dehydrogenase iron containing 1
External IDs	OMIM: 611083 MGI: 1923437 HomoloGene: 5865 GeneCards: ADHFE1
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	66,468,907 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	9,650,898 bp[2]
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gastric mucosa; ; tibialis anterior muscle; ; deltoid muscle; ; gastrocnemius muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; body of stomach; ; biceps brachii; ; tibial nerve;
	Top expressed in
	proximal tubule; ; esophagus; ; nucleus pulposus; ; morula; ; superior frontal gyrus; ; renal pelvis; ; lip; ; secondary oocyte; ; muscle tissue; ; renal calyx;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; metal ion binding; hydroxyacid-oxoacid transhydrogenase activity; alcohol dehydrogenase (NAD+) activity;
Cellular component	mitochondrial matrix; mitochondrion; cytosol;
Biological process	2-oxoglutarate metabolic process; glutamate catabolic process via 2-oxoglutarate;
	Sources:Amigo / QuickGO
Orthologs
	137872
	76187
	ENSG00000147576
	ENSMUSG00000025911
	Q8IWW8
	Q8R0N6
	NM_144650
	NM_175236; NM_001357376; NM_001357377; NM_001357378
	NP_653251
	NP_780445; NP_001344305; NP_001344306; NP_001344307
	Wikidata
View/Edit Human	View/Edit Mouse

Alcohol dehydrogenase, iron containing 1 is a protein that in humans is encoded by the ADHFE1 gene.[5]

Function

The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues.[6]

GRCh38: Ensembl release 89: ENSG00000147576 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025911 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Alcohol dehydrogenase, iron containing 1". Retrieved 2017-06-16.
Kardon T, Noël G, Vertommen D, Schaftingen EV (April 2006). "Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate". FEBS Letters. 580 (9): 2347–50. doi:10.1016/j.febslet.2006.02.082. PMID 16616524. S2CID 46525441.

Deng Y, Wang Z, Gu S, Ji C, Ying K, Xie Y, Mao Y (October 2002). "Cloning and characterization of a novel human alcohol dehydrogenase gene (ADHFe1)". DNA Sequence. 13 (5): 301–6. doi:10.1080/1042517021000011636. PMID 12592711. S2CID 24529446.
Lyon RC, Johnston SM, Panopoulos A, Alzeer S, McGarvie G, Ellis EM (March 2009). "Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1". Chemico-Biological Interactions. 178 (1–3): 283–7. doi:10.1016/j.cbi.2008.10.025. PMID 19013439.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (September 2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.
Tae CH, Ryu KJ, Kim SH, Kim HC, Chun HK, Min BH, Chang DK, Rhee PL, Kim JJ, Rhee JC, Kim YH (March 2013). "Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation". BMC Cancer. 13: 142. doi:10.1186/1471-2407-13-142. PMC 3618294. PMID 23517143.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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