Alberto Bardelli

Alberto Bardelli (born 29 November 1967) is an Italian geneticist and cancer researcher, expert in the field of precision medicine. He is a full professor of histology at the Department of Oncology, University of Turin and Scientific Director of IFOM, the AIRC Institute of Molecular Oncology.

Alberto Bardelli

Career

Alberto Bardelli was born in Turin on 29 November 1967. He studied Biological Sciences at the University of Turin and received his master's degree in 1991. After graduation, he moved to the Ludwig Institute for Cancer Research in London and obtained a PhD in Biochemistry and Molecular Biology from the University College London (UCL).

From 1999 to 2004, Bardelli has been a postdoctoral researcher at the Johns Hopkins University School of Medicine and the Howard Hughes Medical Institute, Baltimore (MD/USA), in the group led by Bert Vogelstein. Here Bardelli began studying the genomics of cancer. During his postdoctoral training at Johns Hopkins, Bardelli published multiple papers in high-profile journals such as Nature and Science.

In 2004, he returned to Italy as director of a research unit dedicated to the study of tumour genomes at the Candiolo Cancer Institute and Dept. of Oncology, University of Turin.

Since 2016, he has been a full professor of histology at the University of Turin.[1][2]

From 2018 to 2020, he served as president of the European Association for Cancer Research (EACR).

He is a member of the scientific committee of the Italian Association for Cancer Research (AIRC).[3]

In 2005, he co-founded the gene editing company Horizon Discovery.

Since April 2022, he has been the scientific director of IFOM, the AIRC Institute of Molecular Oncology, Milan.

Research

Bardelli performed the first comprehensive mutational profile of kinases in colorectal cancers (CRC).[4] He translated these findings into clinical practice by discovering the molecular landscape of response and resistance to EGFR,[5][6] HER2[7] and NTRK1[8] blockades in CRC. One of the main focuses of his research is the study of the emergence and evolution of drug-resistant clones that can be restrained to improve the efficacy of anticancer agents to develop therapies that adapt to a tumour's evolution.[9][10][11] His group used several approaches in their work, including genetic analysis of clinical samples, a large collection of CRC cellular models,[12] patient-derived xenografts (xenopatients), and liquid biopsies.[13][14][15] In the last years his studies uncovered the molecular bases of primary and acquired resistance to anti-EGFR therapies in colorectal tumours. These findings have been rapidly translated into clinically applicable predictive biomarkers, which represent the first example of personalized medicine for colorectal tumours and are used to select patients for therapy.[16]

Bardelli also investigated the use of immunotherapy as a tool for precision medicine in CRC. His studies are built on an unconventional approach that an increased dynamic and mutational load in CRC cells can rouse an otherwise slack immune response, a vital requisite for effective immunosurveillance. Bardelli's team tweaked the clonal evolution of the tumour, via a pharmacological intervention, to provoke the persistent renewal of neoantigens.[17]

Bardelli's studies have been reported in high peer-reviewed scientific journals as Cancer Cell, Nature, JAMA, and Lancet Oncology.

Currently, Bardelli's team uses colorectal cancer models to establish personalized treatment for patients, focusing on:

  • molecular heterogeneity and clonal evolution, both inter-patient and intra-tumour, to overcome the resistance to targeted therapies, and
  • immunotherapy to manipulate the patient's immune system and to find new therapeutic options.

Bardelli's team is composed of more than 20 members, including biologists, PH students, technicians and bioinformatics.

Citations

Bardelli has authored more than 200 scientific articles, of which 100 were written as an independent investigator. His research papers have been cited over 40,000 times.[18] Bardelli has been listed as a Highly Cited Researcher in the field of Clinical Medicine in Clarivate Web of Science (2014, 2018–2020).[19]

Awards
  • 2020 Guido Venosta Award, FIRC AIRC, Presidenza della Repubblica Italiana
  • 2019 Elected Member of the Johns Hopkins Society of Scholars[20]
  • 2017 ESMO Translational Research Award
  • 2017 Fellow of European Molecular Biology Organization (EMBO)
  • 2015 Fellow of the European Academy of Cancer Sciences[21]
  • 2015 Fellow of the Turin Academy of Sciences[22]

Honours

Bardelli was appointed "Officer" of the Order of Merit of the Italian Republic in 2021.

References
  1. "Prof. Alberto Bardelli". Dipartimento di Oncologia (in Italian). University of Turin. Retrieved 2021-05-14.
  2. "IFOM Alberto Bardelli". www.ifom.eu. Retrieved 2021-05-14.
  3. "Tutti i membri". www.airc.it (in Italian). Retrieved 2021-05-14.
  4. Bardelli, Alberto; Parsons, D. Williams; Silliman, Natalie; Ptak, Janine; Szabo, Steve; Saha, Saurabh; Markowitz, Sanford; Willson, James K. V.; Parmigiani, Giovanni; Kinzler, Kenneth W.; Vogelstein, Bert (2003-05-09). "Mutational analysis of the tyrosine kinome in colorectal cancers". Science. 300 (5621): 949. doi:10.1126/science.1082596. ISSN 1095-9203. PMID 12738854. S2CID 85934154.
  5. Siravegna, Giulia; Lazzari, Luca; Crisafulli, Giovanni; Sartore-Bianchi, Andrea; Mussolin, Benedetta; Cassingena, Andrea; Martino, Cosimo; Lanman, Richard B.; Nagy, Rebecca J.; Fairclough, Stephen; Rospo, Giuseppe (2018-07-09). "Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer". Cancer Cell. 34 (1): 148–162.e7. doi:10.1016/j.ccell.2018.06.004. ISSN 1878-3686. PMID 29990497. S2CID 51611215.
  6. Siravegna, Giulia; Mussolin, Benedetta; Buscarino, Michela; Corti, Giorgio; Cassingena, Andrea; Crisafulli, Giovanni; Ponzetti, Agostino; Cremolini, Chiara; Amatu, Alessio; Lauricella, Calogero; Lamba, Simona (July 2015). "Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients". Nature Medicine. 21 (7): 795–801. doi:10.1038/nm.3870. ISSN 1546-170X. PMC 4868598. PMID 26030179.
  7. Van Emburgh, Beth O.; Sartore-Bianchi, Andrea; Di Nicolantonio, Federica; Siena, Salvatore; Bardelli, Alberto (2014-09-12). "Acquired resistance to EGFR-targeted therapies in colorectal cancer". Molecular Oncology. 8 (6): 1084–1094. doi:10.1016/j.molonc.2014.05.003. ISSN 1878-0261. PMC 5528615. PMID 24913799.
  8. Russo, Mariangela; Misale, Sandra; Wei, Ge; Siravegna, Giulia; Crisafulli, Giovanni; Lazzari, Luca; Corti, Giorgio; Rospo, Giuseppe; Novara, Luca; Mussolin, Benedetta; Bartolini, Alice (January 2016). "Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer". Cancer Discovery. 6 (1): 36–44. doi:10.1158/2159-8290.CD-15-0940. hdl:2434/342140. ISSN 2159-8290. PMID 26546295. S2CID 33819773.
  9. Russo, Mariangela; Lamba, Simona; Lorenzato, Annalisa; Sogari, Alberto; Corti, Giorgio; Rospo, Giuseppe; Mussolin, Benedetta; Montone, Monica; Lazzari, Luca; Arena, Sabrina; Oddo, Daniele (2018-06-12). "Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies". Nature Communications. 9 (1): 2287. Bibcode:2018NatCo...9.2287R. doi:10.1038/s41467-018-04506-z. ISSN 2041-1723. PMC 5997733. PMID 29895949.
  10. Arena, Sabrina; Siravegna, Giulia; Mussolin, Benedetta; Kearns, Jeffrey D.; Wolf, Beni B.; Misale, Sandra; Lazzari, Luca; Bertotti, Andrea; Trusolino, Livio; Adjei, Alex A.; Montagut, Clara (2016-02-03). "MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations". Science Translational Medicine. 8 (324): 324ra14. doi:10.1126/scitranslmed.aad5640. hdl:10230/26180. ISSN 1946-6242. PMID 26843189. S2CID 206689568.
  11. Misale, Sandra; Bozic, Ivana; Tong, Jingshan; Peraza-Penton, Ashley; Lallo, Alice; Baldi, Federica; Lin, Kevin H.; Truini, Mauro; Trusolino, Livio; Bertotti, Andrea; Di Nicolantonio, Federica (2015-09-22). "Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers". Nature Communications. 6: 8305. Bibcode:2015NatCo...6.8305M. doi:10.1038/ncomms9305. ISSN 2041-1723. PMC 4595628. PMID 26392303.
  12. Medico, Enzo; Russo, Mariangela; Picco, Gabriele; Cancelliere, Carlotta; Valtorta, Emanuele; Corti, Giorgio; Buscarino, Michela; Isella, Claudio; Lamba, Simona; Martinoglio, Barbara; Veronese, Silvio (2015-04-30). "The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets". Nature Communications. 6: 7002. Bibcode:2015NatCo...6.7002M. doi:10.1038/ncomms8002. ISSN 2041-1723. PMID 25926053. S2CID 205337164.
  13. Siravegna, Giulia; Marsoni, Silvia; Siena, Salvatore; Bardelli, Alberto (September 2017). "Integrating liquid biopsies into the management of cancer". Nature Reviews. Clinical Oncology. 14 (9): 531–548. doi:10.1038/nrclinonc.2017.14. ISSN 1759-4782. PMID 28252003. S2CID 1478003.
  14. Siravegna, Giulia; Bardelli, Alberto (March 2016). "Blood circulating tumor DNA for non-invasive genotyping of colon cancer patients". Molecular Oncology. 10 (3): 475–480. doi:10.1016/j.molonc.2015.12.005. ISSN 1878-0261. PMC 5528968. PMID 26774880.
  15. Bardelli, Alberto; Pantel, Klaus (2017-02-13). "Liquid Biopsies, What We Do Not Know (Yet)". Cancer Cell. 31 (2): 172–179. doi:10.1016/j.ccell.2017.01.002. ISSN 1878-3686. PMID 28196593.
  16. Bardelli, Alberto (2017-05-24). "Medical research: Personalized test tracks cancer relapse". Nature. 545 (7655): 417–418. Bibcode:2017Natur.545..417B. doi:10.1038/545417a. ISSN 1476-4687. PMID 28541318. S2CID 4385197.
  17. Germano, Giovanni; Lamba, Simona; Rospo, Giuseppe; Barault, Ludovic; Magrì, Alessandro; Maione, Federica; Russo, Mariangela; Crisafulli, Giovanni; Bartolini, Alice; Lerda, Giulia; Siravegna, Giulia (2017-12-07). "Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth". Nature. 552 (7683): 116–120. Bibcode:2017Natur.552..116G. doi:10.1038/nature24673. ISSN 1476-4687. PMID 29186113. S2CID 205262351.
  18. "Scopus preview - Bardelli, Alberto - Author details - Scopus". www.scopus.com. Retrieved 2021-05-14.
  19. "Alberto Bardelli's Publons profile". publons.com. Retrieved 2021-05-14.
  20. "Johns Hopkins inducts new members into Society of Scholars". The Hub. 2019-04-10. Retrieved 2021-05-14.
  21. "Fellows| European Academy of Cancer Sciences". www.europeancanceracademy.eu. Archived from the original on 2019-07-04. Retrieved 2021-05-14.
  22. "II sezione: scienze della biologia animale e dell'uomo". www.accademiadellescienze.it. Retrieved 2021-05-14.
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