ATG4D
The human ATG4D gene encodes the protein Autophagy related 4D, cysteine peptidase.[5]
| ATG4D | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | ATG4D, APG4-D, APG4D, AUTL4, autophagy related 4D cysteine peptidase, HsAPG4D | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611340 MGI: 2444308 HomoloGene: 13156 GeneCards: ATG4D | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed.
This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
References
- GRCh38: Ensembl release 89: ENSG00000130734 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000002820 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Autophagy related 4D, cysteine peptidase".
Further reading
- Betin VM, MacVicar TD, Parsons SF, Anstee DJ, Lane JD (April 2012). "A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress". Autophagy. 8 (4): 664–76. doi:10.4161/auto.19227. PMC 3405841. PMID 22441018.
- Betin VM, Lane JD (July 2009). "Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis". Journal of Cell Science. 122 (Pt 14): 2554–66. doi:10.1242/jcs.046250. PMC 2704886. PMID 19549685.
- Mariño G, Uría JA, Puente XS, Quesada V, Bordallo J, López-Otín C (February 2003). "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy". The Journal of Biological Chemistry. 278 (6): 3671–8. doi:10.1074/jbc.M208247200. PMID 12446702.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.