6-Deoxy-5-ketofructose 1-phosphate synthase
6-deoxy-5-ketofructose 1-phosphate synthase (EC 2.2.1.11, DKFP synthase, MJ1585 (gene)) is an enzyme with systematic name 2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase.[1][2] This enzyme catalyses the following chemical reaction
- (1) methylglyoxal + D-fructose 1,6-bisphosphate D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
- (2) methylglyoxal + D-fructose 1-phosphate D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
| 6-deoxy-5-ketofructose 1-phosphate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.2.1.11 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate.
References
- White RH, Xu H (October 2006). "Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii". Biochemistry. 45 (40): 12366–79. doi:10.1021/bi061018a. PMID 17014089.
- Samland AK, Wang M, Sprenger GA (April 2008). "MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity". FEMS Microbiology Letters. 281 (1): 36–41. doi:10.1111/j.1574-6968.2008.01079.x. PMID 18318840.
External links
- 6-deoxy-5-ketofructose+1-phosphate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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