4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
In enzymology, a 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (EC 5.3.1.17) is an enzyme that catalyzes the chemical reaction
- 4-deoxy-L-threo-5-hexosulose uronate 3-deoxy-D-glycero-2,5-hexodiulosonate
| 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.3.1.17 | ||||||||
| CAS no. | 37318-44-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Hence, this enzyme has one substrate, 4-deoxy-L-threo-5-hexosulose uronate, and one product, 3-deoxy-D-glycero-2,5-hexodiulosonate.
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is 4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase. This enzyme is also called 4-deoxy-L-threo-5-hexulose uronate isomerase. This enzyme participates in pentose and glucuronate interconversions.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1X8M, 1XRU, and 1YWK.
References
- Preiss J (1966). "4-Deoxy-L-threo-5-hexosulose uronic acid isomerase". Carbohydrate Metabolism. Methods in Enzymology. Vol. 9. pp. 602–604. doi:10.1016/0076-6879(66)09121-3. ISBN 978-0-12-181809-8.