3-Ketosteroid 9alpha-monooxygenase
3-ketosteroid 9alpha-monooxygenase (EC 1.14.13.142, KshAB, 3-ketosteroid 9alpha-hydroxylase) is an enzyme with systematic name androsta-1,4-diene-3,17-dione,NADH:oxygen oxidoreductase (9alpha-hydroxylating).[1][2][3] This enzyme catalyses the following chemical reaction
- androsta-1,4-diene-3,17-dione + NADH + H+ + O2 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O
| 3-ketosteroid 9alpha-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.142 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3-Ketosteroid 9alpha-monooxygenase is involved in the cholesterol degradation in several bacterial pathogens.
References
- Petrusma M, Dijkhuizen L, van der Geize R (August 2009). "Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9alpha-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificity". Applied and Environmental Microbiology. 75 (16): 5300–7. Bibcode:2009ApEnM..75.5300P. doi:10.1128/AEM.00066-09. PMC 2725467. PMID 19561185.
- Capyk JK, D'Angelo I, Strynadka NC, Eltis LD (April 2009). "Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis". The Journal of Biological Chemistry. 284 (15): 9937–46. doi:10.1074/jbc.M900719200. PMC 2665117. PMID 19234303.
- Capyk JK, Casabon I, Gruninger R, Strynadka NC, Eltis LD (November 2011). "Activity of 3-ketosteroid 9α-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis". The Journal of Biological Chemistry. 286 (47): 40717–24. doi:10.1074/jbc.M111.289975. PMC 3220451. PMID 21987574.
External links
- 3-ketosteroid+9alpha-monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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