3'-demethylstaurosporine O-methyltransferase
In enzymology, a 3'-demethylstaurosporine O-methyltransferase (EC 2.1.1.139) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + 3'-demethylstaurosporine S-adenosyl-L-homocysteine + staurosporine
| 3'-demethylstaurosporine O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.139 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl methionine and 3'-demethylstaurosporine, whereas its two products are S-adenosylhomocysteine and staurosporine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase. Other names in common use include 3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase, and staurosporine synthase.
References
- Weidner S, Kittelmann M, Goeke K, Ghisalba O, Zähner H (July 1998). "3'-Demethoxy-3'-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine". The Journal of Antibiotics. 51 (7): 679–82. doi:10.7164/antibiotics.51.679. PMID 9727395.
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