23S rRNA (guanine748-N1)-methyltransferase

23S rRNA (guanine748-N1)-methyltransferase (EC 2.1.1.188, Rlma(II), Rlma2, 23S rRNA m1G748 methyltransferase, RlmaII, Rlma II, tylosin-resistance methyltransferase RlmA(II), TlrB, rRNA large subunit methyltransferase II) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine748-N1)-methyltransferase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine748 in 23S rRNA S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
23S rRNA (guanine748-N1)-methyltransferase
Identifiers
EC no.2.1.1.188
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme specifically methylates guanine748 at N1 in 23S rRNA.

References
  1. Douthwaite S, Crain PF, Liu M, Poehlsgaard J (April 2004). "The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748". Journal of Molecular Biology. 337 (5): 1073–7. doi:10.1016/j.jmb.2004.02.030. PMID 15046978.
  2. Liu M, Kirpekar F, Van Wezel GP, Douthwaite S (August 2000). "The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA". Molecular Microbiology. 37 (4): 811–20. doi:10.1046/j.1365-2958.2000.02046.x. hdl:1887/3221371. PMID 10972803.
  3. Lebars I, Yoshizawa S, Stenholm AR, Guittet E, Douthwaite S, Fourmy D (January 2003). "Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII". The EMBO Journal. 22 (2): 183–92. doi:10.1093/emboj/cdg022. PMC 140097. PMID 12514124.
  4. Lebars I, Husson C, Yoshizawa S, Douthwaite S, Fourmy D (September 2007). "Recognition elements in rRNA for the tylosin resistance methyltransferase RlmA(II)". Journal of Molecular Biology. 372 (2): 525–34. doi:10.1016/j.jmb.2007.06.068. PMID 17673230.
  5. Douthwaite S, Jakobsen L, Yoshizawa S, Fourmy D (May 2008). "Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I". Journal of Molecular Biology. 378 (5): 969–75. doi:10.1016/j.jmb.2008.03.024. PMID 18406425.
  6. Liu M, Douthwaite S (April 2002). "Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria". Molecular Microbiology. 44 (1): 195–204. doi:10.1046/j.1365-2958.2002.02866.x. PMID 11967079.
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