23S rRNA (guanine1835-N2)-methyltransferase
23S rRNA (guanine1835-N2)-methyltransferase (EC 2.1.1.174, ygjO (gene), rlmG (gene), ribosomal RNA large subunit methyltransferase G) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine1835-N2)-methyltransferase.[1] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + guanine1835 in 23S rRNA S-adenosyl-L-homocysteine + N2-methylguanine1835 in 23S rRNA
| 23S rRNA (guanine1835-N2)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.174 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate.
References
- Sergiev PV, Lesnyak DV, Bogdanov AA, Dontsova OA (November 2006). "Identification of Escherichia coli m2G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA". Journal of Molecular Biology. 364 (1): 26–31. doi:10.1016/j.jmb.2006.09.008. PMID 17010380.
External links
- 23S+rRNA+(guanine1835-N2)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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