2006 Major League Baseball postseason

1. New York Yankees – AL East champions, 97–65[2]
2. Minnesota Twins – AL Central champions, 96–66[3]
3. Oakland Athletics – AL West champions, 93–69[4]
4. Detroit Tigers – 95–67[5]

1. New York Mets – NL East champions, 97–65[6]
2. San Diego Padres – NL West champions, 88–74 (13–5 head-to-head record vs. LAD)[7]
3. St. Louis Cardinals – NL Central champions, 83–78[8]
4. Los Angeles Dodgers – 88–74 (5–13 head-to-head record vs. SD)[9]

Detroit won the series, 3–1.

†: Game was postponed due to rain on October 4

This was the first postseason meeting between the Yankees and Tigers. The Tigers defeated the Yankees in four games to advance to the ALCS for the first time since 1987. It was the first playoff series win by the Tigers since the 1984 World Series.

Games 1 and 2 were split by both teams - the Yankees won Game 1 by an 8-4 score, while the Tigers evened the series with a narrow comeback victory in Game 2. When the series shifted to Detroit for Game 3, the Tigers shut out the Yankees 6-0 off a solid pitching performance from Kenny Rogers. In Game 4, the Tigers jumped out to an 8-0 lead early and didn't relinquish it, as they held on to win 8-3 and advance to the ALCS.

The Tigers and Yankees would meet in the postseason twice more, in the 2011 ALDS and 2012 ALCS, both of which were won by the Tigers.

Oakland won the series, 3–0.

This was the second postseason meeting between the Athletics and Twins. They previously met in the 2002 ALDS, which was won by the Twins. The Athletics swept the Twins to return to the ALCS for the first time since 1992. In Minneapolis, the Twins were held to two runs in each of the first two games as the Athletics went up 2-0 in the series headed to Oakland. The Athletics blew out the Twins in Game 3 to advance to the ALCS.

This was the last time the Athletics won a playoff series until 2020. The Twins would not return to the postseason again until 2009.

New York won the series, 3–0.

This was the first postseason meeting between the Mets and Dodgers since the 1988 NLCS, which was won by the Dodgers in seven games. The Mets swept the Dodgers to return to the NLCS for the first time since 2000.

The Mets prevailed in an offensive slugfest in Game 1. In Game 2, Tom Glavine pitched a solid game and Billy Wagner earned his second straight save of the postseason as the Mets won 4-1 to go up 2-0 in the series headed to Los Angeles. Game 3 was another offensive duel, which the Mets won 9-5 after blowing a 4-0 lead midway through the game.

Both teams would meet again in the 2015 NLDS, which the Mets also won.

St. Louis won the series, 3–1.

In the third postseason meeting between these two teams, the Cardinals once again defeated the Padres, this time in four games, to return to the NLCS for the third straight time.

The Cardinals stole Game 1 on the road in San Diego off a solid pitching performance from Chris Carpenter. Jeff Weaver and four other relievers helped shut out the Padres in Game 2, 2-0, to go up 2-0 in the series headed back home. In St. Louis, the Padres won Game 3 by a 3-1 score despite leaving 14 runners on base. However, Carpenter and Adam Wainwright would shut down the Padres' offense in Game 4 as the Cardinals won 6-2 to advance to the ALCS.

The Padres would not return to the postseason again until 2020.

Detroit won the series, 4–0.

This was a rematch of the 1972 ALCS, which the Athletics won in five games en route to a World Series title. The Tigers swept the Athletics to advance to the World Series for the first time since 1984 (in the process denying a rematch of either the 1931 or 1973 World Series).

Nate Robertson kept the Athletics' offense at bay in Game 1 as the Tigers won 5-1. In Game 2, Justin Verlander won his first postseason game as the Tigers prevailed 8-5 to take a 2-0 series lead headed back to Detroit. In Game 3, Kenny Rogers and closer Todd Jones shut out the Athletics 3-0, and were now one win away from the pennant. The Tigers would complete the sweep with a 6-3 victory in Game 4, capped off by a walk-off three-run home run by Magglio Ordóñez in the bottom of the ninth inning.

As of 2023, this is the last time the Athletics appeared in the ALCS. This was also the Athletics' only ALCS appearance during the "Moneyball" era. The Tigers and Athletics would meet two more times in the postseason, in the ALDS in 2012 and 2013, both won by the Tigers in five games.

The Tigers would win their next and most recent AL pennant in 2012, by sweeping the New York Yankees.

St. Louis won the series, 4-3.

†: Game 1 was postponed due to rain on October 11. Game 2 was subsequently pushed back a day as well.
‡: Game 5 was postponed due to rain on October 16.

This was a rematch of the 2000 NLCS, which the Mets won in five games en route to the World Series. The Cardinals defeated the Mets in seven games to return to the World Series for the second time in three years (in the process denying a rematch of the 1973 World Series).

In Queens, the first two games were split by both teams. When the series moved to St. Louis for Game 3, the Cardinals shut out the Mets by a 5-0 score to go up 2-1 in the series. The Mets then responded with a blowout win in Game 4, and then the Cardinals responded by winning Game 5 to go up 3-2 in the series going back to Queens. The Mets won Game 6 by a 4-2 score to force a seventh game, which the Cardinals would win by a 3-1 score, capped off by a two-run home run by Yadier Molina in the top of the ninth inning of Game 7, which put the Cardinals in the lead for good. Game 7 was the last postseason game ever played at Shea Stadium.

The Mets would make their next postseason appearance in 2015, where they reached the NLCS and swept the Chicago Cubs before falling in the World Series. The Cardinals would win their next NL pennant in 2011 over the Milwaukee Brewers in six games.

St. Louis won the series, 4–1.

†: Game 4 was postponed due to rain on October 25, forcing Game 5 to be subsequently pushed back a day as well.

This was the third World Series matchup between the Tigers and Cardinals. They had previously met in 1934 and 1968, with the Cardinals winning the former and the Tigers winning the latter. Like in 1968, the Tigers were once again down 3-1 in the series, however history would not repeat itself. The 83-win Cardinals finished an improbable upset of the heavily-favored Tigers in Game 5 to win their first World Series title since 1982. It was the first championship for St. Louis since 2000, when the Rams won Super Bowl XXXIV.

In Detroit for Game 1, the Cardinals shocked the Tigers with a 7-2 victory. Game 2 was marred by controversy, as the Tigers’ Kenny Rogers was suspected of using pine tar. Rogers claimed it was a combination of dirt and rosin (both legal), but complied with umpire requests to wash his hands. The Tigers would win Game 2 by a 3-1 score to tie the series. When the series moved back to St. Louis for Game 3, the Cardinals shut out the Tigers 5-0, and in Game 4, the Cardinals overcame a late Tigers lead in the bottom of the seventh to go up 3-1 in the series. The Cardinals then took Game 5 by a 4-2 score, pulling off one of the biggest upsets in World Series history.

The Cardinals would return to the World Series again in 2011 where they defeated the Texas Rangers in seven games. The Tigers wouldn't return to the postseason again until 2011. The Tigers would return to the World Series in 2012, but were swept by the San Francisco Giants.

To date, this is the last time the Tigers won a game in the World Series.