2-Butoxyethanol

2-Butoxyethanol is a solvent for paints and surface coatings, as well as cleaning products and inks.[10][12] Products that contain 2-butoxyethanol include acrylic resin formulations, asphalt release agents, firefighting foam, leather protectors, oil spill dispersants, degreaser applications, photographic strip solutions, whiteboard and glass cleaners, liquid soaps, cosmetics, dry cleaning solutions, lacquers, varnishes, herbicides, latex paints, enamels, printing paste, and varnish removers, and silicone caulk. Products containing this compound are commonly found at construction sites, automobile repair shops, print shops, and facilities that produce sterilizing and cleaning products. It is the main ingredient of many home, commercial and industrial cleaning solutions. Since the molecule has both polar and non-polar ends, 2-butoxyethanol is useful for removing both polar and non-polar substances, like grease and oils. It is also approved by the U.S. FDA to be used as direct and indirect food additives, which include antimicrobial agents, defoamers, stabilizers, and adhesives.[13]

2-Butoxyethanol is commonly produced for the oil industry because of its surfactant properties.[14]

In the petroleum industry, 2-butoxyethanol is a component of fracturing fluids, drilling stabilizers, and oil slick dispersants for both water-based and oil-based hydraulic fracturing.[11] When liquid is pumped into the well, the fracturing fluids are pumped under extreme pressure, so 2-butoxyethanol is used to stabilize them by lowering the surface tension.[11] As a surfactant, 2-butoxyethanol absorbs at the oil-water interface of the fracture.[15] The compound is also used to facilitate the release of the gas by preventing congealing.[11] It is also used as a crude oil–water coupling solvent for more general oil well workovers.[11] Because of its surfactant properties, it is a major constituent (30–60% w/w) in the oil spill dispersant Corexit 9527,[16] which was widely used in the aftermath of the 2010 Deepwater Horizon oil spill.[13]

2-Butoxyethanol can be disposed of by incineration. It was shown that disposal occurs faster in the presence of semiconductor particles.[7] 2-Butoxyethanol usually decomposes in the presence of air within a few days by reacting with oxygen radicals.[22] It has not been identified as a major environmental contaminant, nor is it known to bio-accumulate.[23] 2-Butoxyethanol biodegrades in soils and water, with a half life of 1–4 weeks in aquatic environments.[13]

2-Butoxyethanol most commonly enters the human body system through dermal absorption, inhalation, or oral consumption of the chemical.[7] The ACGIH threshold limit value (TLV) for worker exposure is 20 ppm, which is well above the odor detection threshold of 0.4 ppm. Blood or urine concentrations of 2-butoxyethanol or the metabolite 2-butoxyacetic acid may be measured using chromatographic techniques. A biological exposure index of 200 mg 2-butoxyacetic acid per g creatinine has been established in an end-of-shift urine specimen for U.S. employees.[24][25] 2-Butoxyethanol and its metabolites fall to undetectable levels in urine after about 30 hours in men.[26]

Harmful effects have been observed in nonhuman mammals exposed to high levels of 2-butoxyethanol. Developmental effects were seen in a study that exposed pregnant Fischer 344 rats, a type of laboratory rat, and New Zealand white rabbits to varying doses of 2-butoxyethanol. At 100 ppm (483 mg/m³) and 200 ppm (966 mg/m³) exposure, statistically significant increases were observed in the number of litters with skeletal defects. Additionally, 2-butoxyethanol was associated with a significant decrease in maternal body weight, uterine weight, and number of total implants.[27] 2-Butoxyethanol is metabolized in mammals by the enzyme alcohol dehydrogenase.[26]

Neurological effects have also been observed in animals exposed to 2-butoxyethanol. Fischer 344 rats exposed to 2-butoxyethanol at concentrations of 523 ppm and 867 ppm experienced decreased coordination. Male rabbits showed a loss of coordination and equilibrium after exposure to 400 ppm of 2-butoxyethanol for two days.[28]

When exposed to 2-butoxyethanol in drinking water, both F344/N rats and B63F1 mice showed negative effects. The range of exposure for the two species was between 70 mg/kg body weight per day to 1300 mg/kg body weight per day. Decreased body weight and water consumption were seen for both species. Rats had reduced red blood cell counts and thymus weights, as well as lesions in the liver, spleen, and bone marrow.[27]

Environment and Health Canada recommended that 2-butoxyethanol be added to Schedule 1 of the Canadian Environmental Protection Act, 1999 (CEPA).[29] Under these regulations, products containing 2-butoxyethanol are to be diluted below a certain concentration. Only those in which the user performs the required dilution are required to include it on labelling information.[30]

2-Butoxyethanol is listed in California as a hazardous substance and the state sets an 8 hour average airborne concentration exposure limit at 25 ppm,[31] and in California employers are required to inform employees when they are working with it.[32]

It is approved by the Food and Drug Administration as "an indirect and direct food additive for use as an antimicrobial agent, defoamer, stabilizer and component of adhesives",[13] and also "may be used to wash or assist in the peeling of fruits and vegetables" and "may be safely used as components of articles intended for use in packaging, transporting & holding food".[33] After its deletion from a UN list of substances requiring special toxicity labeling in 1994, and a subsequent petition by the American Chemistry Council, 2-butoxyethanol was removed from the U.S. Environmental Protection Agency's list of hazardous air pollutants in 2004.[34][35] The safety of products containing 2-butoxyethanol as normally used is defended by the industry trade groups the American Chemistry Council[35] and the Soap and Detergent Association.