1-alkylglycerophosphocholine O-acetyltransferase
In enzymology, a 1-alkylglycerophosphocholine O-acetyltransferase (EC 2.3.1.67) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
| 1-alkylglycerophosphocholine O-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.67 | ||||||||
| CAS no. | 76773-96-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are acetyl-CoA and 1-alkyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase. Other names in common use include acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine, 2-O-acetyltransferase, acetyl-CoA:lyso-PAF acetyltransferase, 1-alkyl-2-lysolecithin acetyltransferase, acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase, blood platelet-activating factor acetyltransferase, lyso-GPC:acetyl CoA acetyltransferase, lyso-platelet activating factor:acetyl-CoA acetyltransferase, lysoPAF:acetyl CoA acetyltransferase, PAF acetyltransferase, platelet-activating factor acylhydrolase, platelet-activating factor-synthesizing enzyme, 1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, and lyso-platelet-activating factor:acetyl-CoA acetyltransferase. This enzyme participates in ether lipid metabolism.
References
- Wykle RL, Malone B, Snyder F (1980). "Enzymatic synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and platelet-aggregating lipid". J. Biol. Chem. 255 (21): 10256–60. PMID 7430122.