1-acylglycerophosphocholine O-acyltransferase
In enzymology, a 1-acylglycerophosphocholine O-acyltransferase (EC 2.3.1.23) is an enzyme that catalyzes the chemical reaction
- acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
| 1-acylglycerophosphocholine O-acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.23 | ||||||||
| CAS no. | 9027-64-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 1,2-diacyl-sn-glycero-3-phosphocholine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase. Other names in common use include lysolecithin acyltransferase, 1-acyl-sn-glycero-3-phosphocholine acyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, lysophosphatide acyltransferase, and lysophosphatidylcholine acyltransferase. This enzyme participates in glycerophospholipid metabolism.
References
- Bell RM, Coleman RA (1980). "Enzymes of glycerolipid synthesis in eukaryotes". Annu. Rev. Biochem. 49: 459–87. doi:10.1146/annurev.bi.49.070180.002331. PMID 6250446.
- Hill EE, Lands WE (1968). "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine" (PDF). Biochim. Biophys. Acta. 152 (3): 645–8. doi:10.1016/0005-2760(68)90109-4. hdl:2027.42/33183. PMID 5661029.
- Miki Y, Hosaka K, Yamashita S, Handa H, Numa S (1977). "Acyl-acceptor specificities of 1-acylglycerolphosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase resolved from rat liver microsomes". Eur. J. Biochem. 81 (3): 433–41. doi:10.1111/j.1432-1033.1977.tb11968.x. hdl:2433/221697. PMID 598375.
- van den Bosch H, van Golde LM, Eibl H, van Deenen LL (1967). "The acylation of 1-acylglycero-3-phosphorylcholines by rat-liver microsomes". Biochim. Biophys. Acta. 144 (3): 613–23. doi:10.1016/0005-2760(67)90050-1. PMID 6078124.