(S)-tetrahydroprotoberberine N-methyltransferase
In enzymology, a (S)-tetrahydroprotoberberine N-methyltransferase (EC 2.1.1.122) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine
| (S)-tetrahydroprotoberberine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.122 | ||||||||
| CAS no. | 106878-42-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl methionine and (S)-7,8,13,14-tetrahydroprotoberberine, whereas its two products are S-adenosylhomocysteine and cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase. This enzyme is also called tetrahydroprotoberberine cis-N-methyltransferase. This enzyme participates in alkaloid biosynthesis i.
References
- Rueffer M, Zumstein G, Zenk MH (1990). "Partial purification and characterization of S-adenosyl-L-methionine:(S)-tetrahydroprotoberberine cis-N-methyltransferase from suspension-cultured cells of Eschscholtzia and Corydalis" (PDF). Phytochemistry. 29 (12): 3727–3733. doi:10.1016/0031-9422(90)85321-6.
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