Epistemological knowledge is applied whenever we voluntarily acquire or use knowledge. To acquire knowledge, one must know how to recognize and evaluate it when one finds it, and one must know how to give oneself the means to acquire it. Epistemological knowledge is always at the heart of knowledge. It accompanies all forms of knowledge. None can do without it, because to know, one must know how to recognize knowledge.

Epistemological knowledge is of paramount importance for the research and evaluation of the principles of science. Mathematicians who discuss the principles of mathematics do a job that is at the same time mathematical and epistemological. The same goes for all other sciences. Basic research is therefore a kind of applied epistemological research.

The applications of epistemology can be very concrete. In all practical areas where the acquisition and use of good knowledge is of crucial importance, so almost always, a solid epistemological knowledge can prove its usefulness. Pedagogy and cognitive therapy are directly relevant, but more generally most issues of importance to humans depend on our ability to collectively acquire and use knowledge: public health, ecology, economics and finance, justice and democracy, truth and lies in the media, reliability and safety of equipment ...

Artificial intelligence is also an application of epistemology, because we can develop new techniques by imitating life.